Synthesis and Biological Evaluation of Kojyl Thioether Derivatives as Tyrosinase Inhibitors

) is well known depigmenting agent that is used to reduce melanin content by inhibition of tyrosinase. Although hydroquinone exhibits highly potent depigmenting activity, its application in cosmetics isrestricted because of its severe side effects such as melanocyte destruction, irritative dermatitis, and contact dermatitis. To over-come this disadvantage, its glycoside derivative, arbutin