Why the study?
Does triamcinolone acetonide injection form large aggregates in human serum compared to non-serum controls or other particulate steroids?
Does triamcinolone acetonide injection form large aggregates in human serum compared to non-serum controls or other particulate steroids?
Triamcinolone acetonide forms fewer large aggregates in human serum than in non-serum controls, but still forms larger aggregates than other particulate steroids, which is relevant for safety considerations during epidural steroid injections.
Answers are grounded in this paper and cite their sources.
May inform epidural steroid selection to reduce aggregation risks; leaves open human trials on clinical safety.
Fewer large triamcinolone aggregates were noted in the presence of serum when compared to the non-serum control groups. However, when compared to previously studied particulate steroids, it had the largest aggregates when added to serum.
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Wahezi et al. (2019) studied this question.
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