Population
In vitro assays and dog models
Design
Preclinical
Authors
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Supports preclinical development of oral FXa inhibitors; leaves open human translation and trials.
R-142086 is a newly synthesized cinnamyl derivative that demonstrates potent, orally active Factor Xa inhibition and anticoagulant activity in preclinical dog models.
Noguchi et al. (2009) studied this question.
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