The Aza‐Achmatowicz Reaction: Facile Entry into Functionalized Piperidinones

Abstract Amongst the various conversions that are known to transform the furan moiety into other functional groups or heterocyclic rings, the Achmatowicz reaction and the corresponding aza‐modification stand out as broadly applicable oxidative rearrangements. Both reactions are synthetically useful transformations resulting either in pyranone or piperidinone structures, containing ample synthetic opportunities for further functionalization. In this review, we will provide a literature overview of the aza‐Achmatowicz reaction, including application of the resulting piperidinones in the synthesis of biologically active compounds and natural products.