Stereodivergent Total Synthesis of (+)‐Aspergillide B and (+)‐7‐epi‐Aspergillide A

The stereoselective total syntheses of (+)‐aspergillide B and (+)‐7‐epi‐aspergillide A were achieved. The key reactions include Noyori's asymmetric transfer hydrogenation, an Achmatowicz rearrangement, a Ferrier‐type alkynylation, a hydrosilylation–protodesilylation, a CBS (Corey–Bakshi–Shibata) oxazaborolidine reduction, a Yamaguchi macrolactonization, and a Mitsunobu macrolactonization.