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April 1, 2002Molecular Human ReproductionOpen Access

Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases

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Population

Hydatidiform mole and choriocarcinoma tissues, and normal first trimester placenta

Design

Preclinical

Authors

TOTomomitsu OkamotoChukyo Hospital

Discussion

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Implication

Hypothesis-generating for matrix dysregulation in gestational trophoblastic disease; leaves open clinical relevance pending human validation.

Structured PICO

P
Population
Hydatidiform mole and choriocarcinoma tissues, and normal first trimester placenta
C
Comparator
Normal first trimester placenta
O
Outcome
Levels of type IV collagenases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2)surrogate

Decreased expression of TIMP-2 and increased MMP activity may be involved in the pathogenesis of gestational trophoblastic diseases.

Cite This Study

Tomomitsu Okamoto (2002) studied this question.

synapsesocial.com/papers/69dd5c6d7dbdc4ad1440c5efhttps://doi.org/10.1093/molehr/8.4.392
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EMA/CO for high-risk gestational trophoblastic tumors: results from a cohort of 272 patients.1997 · 314 citations
  2. 2BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE1986 · 690 citations
  3. 3Tissue Inhibitor of Metalloproteinase (TIMP-2)1989 · 899 citations