Alternative splicing of the Tmem16a gene is highly complex and likely serves to diversify the function of the TMEM16A calcium-activated chloride channel in physiological and pathophysiological conditions.
May diversify TMEM16A function in disease; leaves open human validation before clinical consideration.
Our results suggest that Tmem16a gene is significantly more complex than previously described. The complexity is especially evident in the region spanning exons 6 through 16 where a number of the alternative splicing events are thought to affect calcium sensitivity, voltage dependence and the kinetics of activation and deactivation of this calcium-activated chloride channel. The identification of multiple Tmem16a splice variants suggests that alternative splicing is an exquisite mechanism that operates to diversify TMEM16A channel function in both physiological and pathophysiological conditions.
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O’Driscoll et al. (2011) studied this question.
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