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March 19, 2014Organic Letters

Copper-Catalyzed α-Methylenation of Benzylpyridines Using Dimethylacetamide as One-Carbon Source

Masaki Itoh Koji Hirano Tetsuya Satoh Masahiro Miura

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Abstract

The direct α-methylenation of benzylpyridines was achieved using N,N-dimethylacetamide (DMA) as a one-carbon source under copper catalysis. An intermediary species was detected at an early stage, and a possible mechanism was proposed. Additionally, α-oxygenation and dimerization of benzylpyridines could also be performed efficiently.

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Cite This Study

Itoh et al. (2014) studied this question.

synapsesocial.com/papers/69dd5d197808b00a4799d1c2 https://doi.org/10.1021/ol500655k

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