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June 1, 2020Journal of Hematology & OncologyOpen Access

XPO1-dependent nuclear export as a target for cancer therapy

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Authors

NANancy G. AzizianYLYulin Li

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Overview

Review demonstrates the therapeutic potential of targeting XPO1-mediated nuclear export in human cancers, highlighting recent clinical progress with selective inhibitors.

Key Points

  • To review the physiological functions of the nuclear export receptor XPO1, its deregulation in oncogenesis, and current clinical developments in XPO1-targeted therapeutics.
  • Synthesized molecular mechanisms of XPO1-mediated nuclear-cytoplasmic transport involving proteins and RNA species.
  • Summarized the pharmacological discovery and development of selective inhibitor of nuclear export (SINE) compounds.
  • Assessed recent clinical trial data evaluating SINE inhibitors across cancer indications and outlined emerging directions for therapeutic application.
  • XPO1 is frequently overexpressed or mutated in human malignancies, functioning as an oncogenic driver by mislocalizing key regulatory cargo away from the nucleus.
  • Therapeutic inhibition using SINE compounds suppresses aberrant nuclear export, reinstating tumor-suppressive pathways and demonstrating clinical efficacy across diverse cancers.

Cite This Study

Azizian et al. (2020) studied this question.

synapsesocial.com/papers/69dd5da77dbdc4ad1440c67ahttps://doi.org/10.1186/s13045-020-00903-4
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Also Consider

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  1. 1Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.1994 · 460 citations
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  4. 4Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.1983 · 167 citations
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