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Reveals elevated tissue advanced glycation end products linked to glucose exposure in dialysis patients, highlighting a mechanism for systemic cardiovascular disease.
Cumulative metabolic stress and transient hyperglycemia results in grossly elevated levels of tissue AGE in dialysis patients. In PD patients, this high level of AGE deposition is associated with historical glucose exposure. This observation provides a previously unappreciated potential link between PD exposure to glucose and systemic cardiovascular disease.
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McIntyre et al. (2009) studied this question.
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