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April 25, 2023Pharmaceuticals171 citationsOpen Access

Lactylation-Related Gene Signature Effectively Predicts Prognosis and Treatment Responsiveness in Hepatocellular Carcinoma

ZCZhe ChengHHHuichao HuangMLMaoyu Li

Key Points

  • To evaluate the efficacy of a lactylation-related gene signature for predicting prognosis and therapeutic responsiveness in hepatocellular carcinoma.
  • Constructed a predictive prognostic model based on lactylation-related genes in hepatocellular carcinoma samples.
  • Analyzed biological pathway enrichment and evaluated sensitivity to targeted therapeutics and immunotherapy across risk-score groups.
  • The lactylation-related gene signature exhibited robust efficiency in predicting clinical outcomes for hepatocellular carcinoma.
  • The glycolysis pathway showed significant enrichment within hepatocellular carcinoma tumor samples.
  • A low-risk score was associated with superior therapeutic responsiveness to multiple targeted therapies and immunotherapy.

Abstract

The lactylation-related model exhibited robust predictive efficiency in HCC. The glycolysis pathway was enriched in the HCC tumor samples. A low-risk score indicated better treatment response to most targeted drugs and immunotherapy. The lactylation-related gene signature could be used as a biomarker for the effective clinical treatment of HCC.

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Cite This Study

Cheng et al. (2023) studied this question.

synapsesocial.com/papers/69dd5f16629747396240c95fhttps://doi.org/10.3390/ph16050644
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