Why the study?
POCD commonly occurs after surgery, leading to extended hospital stays, heightened mortality, and increased risk of Alzheimer's disease, prompting research into its molecular mechanisms and preventive strategies.
This review highlights the significant burden of postoperative cognitive dysfunction, particularly following cardiovascular surgery, and summarizes current research on its mechanisms and prevention.
Substantial POCD burden after cardiovascular surgery warrants clinical vigilance; this review leaves open optimal prevention strategies.
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer's disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.
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Zhao et al. (2024) studied this question.
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