Why the study?
Does adherence and persistence with direct oral anticoagulants differ between anticoagulant-naïve and anticoagulant-experienced adults with atrial fibrillation?
Does adherence and persistence with direct oral anticoagulants differ between anticoagulant-naïve and anticoagulant-experienced adults with atrial fibrillation?
Real-world adherence and persistence to DOACs in adults with atrial fibrillation decline over time and are particularly suboptimal in anticoagulant-naïve patients, highlighting a need for targeted patient education.
Answers are grounded in this paper and cite their sources.
May warrant closer adherence monitoring in anticoagulant-naïve atrial fibrillation patients; leaves open optimal intervention strategies.
Medication adherence and persistence with DOACs declined over time and both were suboptimal and lower (at 6 and 12 mo postindex) in AC-naïve compared to AC-experienced patients. These findings can help target future strategies or interventions for patient education and long-term AC management especially in those patients naïve to DOAC therapy. Future investigation should examine potential reasons for differences in DOAC adherence and persistence between AC-experienced versus AC-naïve patients and the implications for patient outcomes.
No takes yet. Share an insight, caveat, or question.
Manzoor et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: