Characterization of a new animal model for evaluation and treatment of back pain due to lumbar facet joint osteoarthritis

This is the authors' abstract. We don't add key points for this paper.

Our findings demonstrate that MIA injection provides a useful model for the study of OA changes in the facet joint and indicate that facet joint degeneration is a major cause of chronic low back pain. The treatment results suggest that classes of drugs that are widely used to treat OA, such as nonsteroidal antiinflammatory drugs, may have limited efficacy once joint destruction is complete.