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Assess whether ribosomal protein genes maintain sufficient expression stability across diverse tissues to serve as universal reference standards.

March 25, 2008PLoS ONEOpen Access

Using Ribosomal Protein Genes as Reference: A Tale of Caution

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Assess whether ribosomal protein genes maintain sufficient expression stability across diverse tissues to serve as universal reference standards.
Conducted a meta-analysis evaluating mRNA expression levels and stability across candidate genes.
Analyzed statistical and biological patterns of gene expression variation across multiple tissues.
Ribosomal protein genes demonstrated the highest overall expression stability among all genes evaluated in the meta-analysis.
Gene expression exhibited significant tissue-dependent variation, indicating that ribosomal protein genes cannot be considered true reference genes.

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Implication

Meta-analysis reveals tissue-dependent mRNA expression variation in ribosomal protein genes, indicating they are unsuitable as universal reference genes.

Cite This Study

Thorrez et al. (2008) studied this question.

synapsesocial.com/papers/69dd6147fb7610310c102b1e https://doi.org/10.1371/journal.pone.0001854

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Implication

Meta-analysis reveals tissue-dependent mRNA expression variation in ribosomal protein genes, indicating they are unsuitable as universal reference genes.

Using Ribosomal Protein Genes as Reference: A Tale of Caution

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Discussion

Implication

Cite This Study

Using Ribosomal Protein Genes as Reference: A Tale of Caution

Key Points

Discussion

Implication

Cite This Study

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