Why the study?
There are no definitive diagnostic criteria enabling universal identification of LBBB-induced dilated cardiomyopathy and no defined therapeutic approach in this subgroup of patients.
Does cardiac resynchronization therapy improve left ventricular function in patients with LBBB-induced dilated cardiomyopathy compared to medical therapy alone?
Does cardiac resynchronization therapy improve left ventricular function in patients with LBBB-induced dilated cardiomyopathy compared to medical therapy alone?
Recognizing LBBB-induced dilated cardiomyopathy as a distinct entity is clinically important because these patients may benefit from early cardiac resynchronization therapy.
Left bundle branch block (LBBB) is a frequent finding in patients with heart failure (HF), particularly in those with dilated cardiomyopathy (DCM). LBBB has been commonly described as a consequence of DCM development. However, a total recovery of left ventricular (LV) function after cardiac resynchronization therapy (CRT), observed in patients with LBBB and DCM, has led to increasing acknowledgement of LBBB-induced dilated cardiomyopathy (LBBB-iDCM) as a specific pathological entity. Its recognition has important clinical implications, as LBBB-iDCM patients may benefit from an early CRT strategy rather than medical HF therapy only. At present, there are no definitive diagnostic criteria enabling the universal identification of LBBB-iDCM, and no defined therapeutic approach in this subgroup of patients. This review compiles the main findings about LBBB-iDCM pathophysiology and the current proposed diagnostic criteria and therapeutic approach.
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Marques et al. (2024) studied this question.
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