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December 2, 2014Pharmaceutical ResearchOpen Access

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

Dan Lü Jin Y. Jin Sandhya Girish Priya Agarwal Dongwei Li Saileta Prabhu Randall Dere Ola M. Saad Denise Nazzal Neelima Koppada Saroja Ramanujan Chee M. Ng

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Abstract

Our model improves the understanding of ADC catabolism, which may provide useful insights when designing future ADCs.

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Cite This Study

Lü et al. (2014) studied this question.

synapsesocial.com/papers/69dd61d40a7b4bc8c4101e40 https://doi.org/10.1007/s11095-014-1585-y

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Antibody Delivery of Drugs and Radionuclides: Factors Influencing Clinical PharmacologyOriginal Research · 2011 · 34 citations
2A Phase I Study of the Anti-CD79b Antibody-Drug Conjugate (ADC) DCDS4501A Targeting CD79b in Relapsed or Refractory B-Cell Non-Hodgkin's Lymphoma (NHL)Early-Phase Clinical Trial · 2012 · 16 citations
3Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical CatabolismEarly-Phase Clinical Trial · 2012 · 141 citations
4Strategies to Address Drug Interaction Potential for Antibody–Drug Conjugates in Clinical DevelopmentRisk Assessment · 2013 · 21 citations
5Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast CancerEarly-Phase Clinical Trial · 2012 · 53 citations

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