Why the study?
Do atrial pacing and isoproterenol reverse atrial mechanical stunning after cardioversion of atrial fibrillation?
Do atrial pacing and isoproterenol reverse atrial mechanical stunning after cardioversion of atrial fibrillation?
Atrial mechanical stunning after short-duration AF can be reversed by pacing and isoproterenol, indicating a functional contractile apparatus, while long-duration AF involves additional factors.
Supports reversal of stunning after short-duration AF; leaves open mechanisms and clinical utility in long-duration cases.
Atrial pacing at increased rates and isoproterenol can reverse atrial mechanical stunning associated with short-duration AF. In contrast, long-duration AF is associated with an attenuated response to these maneuvers. These findings suggest a functional contractile apparatus in the mechanically remodeled atrium caused by AF; however, with longer durations of AF, additional factors may determine atrial mechanical function.
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Sanders et al. (2003) studied this question.
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