Probing Bacterial‐Toxin Inhibition with Synthetic Glycopolymers Prepared by Tandem Post‐Polymerization Modification: Role of Linker Length and Carbohydrate Density

Probing the depths: A tandem post-polymerization modification strategy was used to systematically probe the multivalent inhibition of a bacterial toxin as a function of linker length (see scheme), carbohydrate density, and glycopolymer chain length. Guided by structural-biology information, the binding-pocket depth of the toxin was probed and used as a means to specifically improve inhibition of the toxin by the glycopolymer.