Cohort study finds no increase in postoperative complications with GLP-1 agonists after total knee arthroplasty, indicating their safety for perioperative management.
This study found that GLP-1 agonist use was not associated with increased medical or surgical complication rates in patients with diabetes undergoing TKA and was associated with lower rates of extended hospital stays after surgery. Given the potential for increased glycemic control and weight loss in patients using GLP-1 agonists, more data are needed to delineate the potential role of GLP-1 agonists in preoperative optimization of patients with diabetes prior to joint arthroplasty to minimize postoperative complications.
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Heo et al. (2024) studied this question.
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