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November 23, 2016Proceedings of the National Academy of SciencesOpen Access

Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas

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Authors

YLYinghui LiHCHui ChengWCWee Joo Chng

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Li et al. (2016) studied this question.

synapsesocial.com/papers/69dd6f3a30fba8aacf40c679https://doi.org/10.1073/pnas.1611106113
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  1. 1Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells2015 · 77 citations
  2. 2Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation2016 · 164 citations
  3. 3Highly Recurrent <i>TERT</i> Promoter Mutations in Human Melanoma2013 · 1,859 citations
  4. 4Telomerase reverse transcriptase promotes cancer cell proliferation by augmenting tRNA expression2016 · 137 citations