October 22, 2025SHILAP Revista de lepidopterología9 citationsOpen Access
Cardiometabolic multimorbidity, social activity, and joint trajectories of physical disability, depressive symptom, and cognitive function in mid-to-late life: a multicohort study
Structured PICO
Does cardiometabolic multimorbidity and social inactivity affect trajectories of physical disability, depressive symptoms, and cognitive function in mid-to-late life?
P
Population
Individuals in mid-to-late life
I
Intervention
Cardiometabolic multimorbidity (CMM) and social inactivity (evaluated as exposures)
O
Outcome
Joint trajectories of physical disability, depressive symptom, and cognitive function
Cardiometabolic multimorbidity combined with social inactivity accelerates physical, depressive, and cognitive decline in mid-to-late life.
Abstract
CMM was associated with worse levels, faster progression, and concurrent deterioration in physical disability, depressive symptom, and cognitive function, with the poorest trajectories among those who were socially inactive. This underscores the importance of implementing prevention strategies that integrate physical, psychological, cognitive, and social activities.