Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPARγ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.
No takes yet. Share an insight, caveat, or question.
Jiang et al. (2017) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: