Key result
Each 1-unit CALLY index increase is linked to ~3% lower adolescent obesity odds, outperforming traditional markers.
Why the study?
Does the CALLY index predict obesity in adolescents better than traditional inflammatory markers?
Cross-Sectional (n=2,188)
Does the CALLY index predict obesity in adolescents better than traditional inflammatory markers?
The CALLY index may serve as a valuable tool for early screening and intervention in adolescent obesity, offering better predictive accuracy than traditional inflammatory markers.
Answers are grounded in this paper and cite their sources.
May improve early screening for adolescent obesity; extends beyond traditional inflammatory markers but requires prospective validation.
OBJECTIVE: To investigate the association between the C-reactive protein-Albumin-lymphocyte (CALLY) index and obesity in adolescents, and evaluate its predictive performance compared to traditional inflammatory markers. METHODS: ) and discrimination were evaluated, with sensitivity analyses for model specifications. RESULTS: The CALLY index was inversely associated with obesity (OR = 0.968, 95% CI 0.958-0.977, p < 0.001), with each 1-unit increase reducing obesity odds by 3.20%. This association remained significant after multivariate adjustment and varied by age, race, and physical activity. The standalone AUC of CALLY (0.743) significantly outperformed traditional markers (PLR: 0.515, NLR: 0.546, SII: 0.593, SIRI: 0.598). Combined with covariates, AUC increased to 0.774 (DeLong test p < 0.001). At the cutoff of 15.10, CALLY achieved > 80% sensitivity with a positive likelihood ratio near 2.0. CONCLUSIONS: The CALLY index is a robust and independent predictor of obesity in adolescents, outperforming traditional inflammatory markers. Its integration with traditional covariates further enhances predictive accuracy, suggesting that the CALLY index could be a valuable tool for early screening and intervention in adolescent obesity.
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Li et al. (2026) conducted a cross-sectional in Adolescent obesity (n=2,188). CALLY index vs. Traditional inflammatory markers (NLR, PLR, SII, SIRI) was evaluated on Obesity (BMI ≥ 95th percentile) (OR 0.968, 95% CI 0.958-0.977, p=<0.001). Each 1-unit increase in the CALLY index was associated with a 3.20% reduction in the odds of obesity among adolescents (OR 0.968), significantly outperforming traditional inflammatory markers.
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