This systematic review reveals the impact of frailty on mortality in acute ischemic stroke patients receiving reperfusion therapies, highlighting its significance in treatment decisions.
Frailty has a consistent association with mortality at different time points after AIS reperfusion therapies. Despite some study heterogeneity, there is evidence that pre-stroke frailty is associated with increased mortality after treatment, though not with increased risks of symptomatic intracerebral haemorrhage or post-stroke disability. These findings suggest that routine pre-morbid frailty assessment may inform the decision-making process for AIS reperfusion treatment administration. This study highlights the need for large multi-centre prospective trials.
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Varma et al. (2026) studied this question.
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