Why the study?
Does a single oral dose of sildenafil improve pulmonary vasodilation compared to iNO in patients with pulmonary arterial hypertension?
Population
Patients with pulmonary arterial hypertension
Comparison
Single oral dose of sildenafil vs Inhaled nitric oxide (iNO)
Design
Other
Authors
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Supports oral sildenafil as potential alternative to iNO in PAH; leaves open need for prospective randomized trials.
Does a single oral dose of sildenafil improve pulmonary vasodilation compared to iNO in patients with pulmonary arterial hypertension?
A single oral dose of sildenafil provides effective and selective pulmonary vasodilation comparable to iNO, with favorable hemodynamic effects on cardiac output and wedge pressure.
Michelakis et al. (2002) studied this question.
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