Does clozapine trigger distal renal tubular acidosis in a patient with a heterozygous ATP6V0A4 variant?
Highlights a potential gene-drug interaction predisposing patients with ATP6V0A4 variants to clozapine-induced distal renal tubular acidosis.
This case highlights a potential gene-drug interaction, in which an ATP6V0A4 variant predisposed the patient to clozapine-induced dRTA. Recognizing genetic susceptibility is essential when dRTA arises in the context of medications not typically associated with the condition, to inform both diagnosis and management.
Kumagai et al. (Wed,) studied this question.