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September 30, 2010HepatologyOpen Access

Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians

Felix Stickel Stephan Buch Katharina Lau Henriette E. Meyer zu Schwabedissen Thomas Berg Monika Ridinger Marcella Rietschel Clemens Schafmayer Felix Braun Holger Hinrichsen Rainer Günther Alexander Arlt Marcus Seeger Sebastian Müller Helmut K. Seitz Michael Soyka Markus M. Lerch Frank Lammert Christoph Sarrazin Ralf Kubitz Dieter Häussinger Claus Hellerbrand D. C. Bröring Stefan Schreiber Falk Kiefer Rainer Spanagel Karl Mann Christian Datz Michael Krawczak Norbert Wodarz Henry Völzke Jochen Hampe

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Abstract

Genotype PNPLA3 rs738409(GG) is associated with alcoholic liver cirrhosis and elevated aminotransferase levels in alcoholic Caucasians.

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Stickel et al. (2010) studied this question.

synapsesocial.com/papers/69de619c7ed287395e558a8a https://doi.org/10.1002/hep.24017

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The natural history of nonalcoholic fatty liver: A follow-up studyCohort Study · 1995 · 925 citations
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3Risk factors of fibrosis in alcohol-induced liver diseaseOriginal Research · 2002 · 392 citations
4Genetic Predisposition to Organ‐Specific Endpoints of AlcoholismCohort Study · 1996 · 172 citations
5Evidence of Genetic Predisposition to Alcoholic Cirrhosis and Psychosis: Twin Concordances for Alcoholism and Its Biological End Points by Zygosity among Male VeteransOriginal Research · 1981 · 456 citations

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