Why the study?
Does Roux-en-Y gastric bypass alter the disposition of immediate-release and controlled-release metoprolol formulations?
Does Roux-en-Y gastric bypass alter the disposition of immediate-release and controlled-release metoprolol formulations?
Metoprolol disposition is not significantly altered after Roux-en-Y gastric bypass, suggesting no major dose adjustments are needed.
Metoprolol disposition unaffected post-RYGB in this small cohort; hypothesis-generating and requires larger prospective validation before guiding dosing.
The disposition of metoprolol from an immediate-release and a controlled-release formulation was not significantly altered after RYGB; there was a tendency to an increase, which was also predicted by PBPK modelling and simulation.
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Gesquiere et al. (2015) studied this question.
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