Effect of Sequential, Colocalized Radiofrequency and Pulsed Field Ablation on Cardiac Lesion Size and Histology
Why the study?
Does sequential, colocalized radiofrequency and pulsed field ablation increase cardiac lesion size compared to either modality alone in a preclinical swine model?
Population
Preclinical swine model (n=4) undergoing right and left ventricular ablations
Comparison
Sequential, colocalized radiofrequency and… vs Pulsed field ablation alone or radiofrequency…
Design
Preclinical
Follow-up
2 hours
Authors
Discussion
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Member takes
Implication
May enhance lesion size in animal models; leaves open clinical translation to human ablation.
Structured PICO
Does sequential, colocalized radiofrequency and pulsed field ablation increase cardiac lesion size compared to either modality alone in a preclinical swine model?
P
Population
Preclinical swine model (n=4) undergoing right and left ventricular ablations
I
Intervention
Sequential, colocalized radiofrequency (50 W for 10 s, 15 mL/min irrigation) and pulsed field ablation (unipolar, biphasic pulses, PF index 300, 4-mL/min irrigation) delivered via a force-sensing 3.5-mm irrigated-tip catheter
C
Comparator
Pulsed field ablation alone or radiofrequency ablation alone
O
Outcome
Lesion depth and width, and histology assessed 2 hours post-ablationsurrogate
Sequential, colocalized radiofrequency and pulsed field ablation significantly increases cardiac lesion size compared to either modality alone in a preclinical model.
Cite This Study
Verma et al. (2025) studied this question.