The synthesis of N ‐arylisatoic anhydrides 3 has been accomplished by using a two‐step process. The key reaction in the sequence is the direct N ‐arylation of isatin with an aryl bromide in the presence of cupric oxide. Subsequent oxidation of the resulting N ‐aryl isatin 2 with m ‐chloroperoxybenzoic acid furnishes the desired products.
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Gary M. Coppola (1987) studied this question.
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