Key result
hiPS-CM sheets improve cardiac function in a porcine model of ischemic cardiomyopathy.
Why the study?
A newly developed culture system yields large numbers of highly pure hiPS-CMs and may improve cardiac function after ischemic cardiomyopathy, supporting clinical use in cardiac regeneration therapy.
Do human induced pluripotent stem cell-derived cardiomyocyte sheets improve cardiac function in a porcine ischemic cardiomyopathy model?
Do human induced pluripotent stem cell-derived cardiomyocyte sheets improve cardiac function in a porcine ischemic cardiomyopathy model?
Human induced pluripotent stem cell-derived cardiomyocyte sheets demonstrate feasibility and potential to improve cardiac function in a preclinical porcine model of ischemic cardiomyopathy.
hiPS-CM sheets improved function in porcine ischemic cardiomyopathy; hypothesis-generating, should not yet change practice.
The culture system used yields a large number of highly pure hiPS-CMs, and hiPS-CM sheets could improve cardiac function after ischemic cardiomyopathy. This newly developed culture system and the hiPS-CM sheets may provide a basis for the clinical use of hiPS cells in cardiac regeneration therapy.
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Kawamura et al. (2012) studied this question. Human induced pluripotent stem cell-derived cardiomyocyte sheets improved cardiac function in a porcine model of ischemic cardiomyopathy.
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