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August 14, 2010Lara D. Veeken

Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis

Thierry Dervieux Rong Zablocki Joel M. Kremer

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Abstract

The selective emergence of long-chain MTXPGs is function of dose, time of exposure and hence dosage intensity. Switching from oral to parenteral MTX produces a selective accumulation of longer chain MTXPGs that are known to be more potent inhibitors of de novo purine biosynthesis than shorter chain MTXPGs.

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Dervieux et al. (2010) studied this question.

synapsesocial.com/papers/69de6d37fd84e72eb2558525 https://doi.org/10.1093/rheumatology/keq216

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatmentRCT · 2005 · 1,786 citations
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3Double‐blind randomized controlled clinical trial of the interleukin‐6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexateClinical Trial · 2006 · 790 citations
4Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD StudyRCT · 2008 · 541 citations
5Methotrexate in rheumatoid arthritis. a five‐year prospective multicenter studyCohort Study · 1994 · 220 citations

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