PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 1, 2001Nucleic Acids Research663 citationsOpen Access

The TRANSFAC system on gene expression regulation

View Full Paper
EWEdgar Wingender

Key Points

  • The main aim is to provide a comprehensive database of transcription factors and their regulatory roles in gene expression.
  • Quantitative extension of the TRANSFAC database with multiple modules.
  • Integration of data on mutational impacts in regulatory regions, signal transduction pathways, and gene expression origins.
  • Development of routines to identify transcription factor binding sites and regulatory components.
  • The TRANSFAC system now includes additional modules like PathoDB and TRANSPATH, improving data availability.
  • New information regarding pathological mutations enhances understanding of gene regulation.
  • Tools for identifying transcription factor interactions and locations within regulatory networks have been established.

Abstract

The TRANSFAC database on transcription factors and their DNA-binding sites and profiles (http://www.gene-regulation.de/) has been quantitatively extended and supplemented by a number of modules. These modules give information about pathologically relevant mutations in regulatory regions and transcription factor genes (PathoDB), scaffold/matrix attached regions (S/MARt DB), signal transduction (TRANSPATH) and gene expression sources (CYTOMER). Altogether, these distinct database modules constitute the TRANSFAC system. They are accompanied by a number of program routines for identifying potential transcription factor binding sites or for localizing individual components in the regulatory network of a cell.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Edgar Wingender (2001) studied this question.

synapsesocial.com/papers/69de6e29210a0977fce942a4https://doi.org/10.1093/nar/29.1.281
Ask AI
Helpful
Bookmark
Share
View Full Paper