Left Atrial Appendage Closure Compared With Oral Anticoagulants for Patients With Atrial Fibrillation: A Systematic Review and Network Meta‐Analysis

Figures

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  Figure 1. Preferred Reporting Items for Systematic Reviews and Meta‐Analyses 2020 flow diagram.

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  Figure 2. Network plot. The nodes represent the treatments to be compared and the lines the direct comparisons between them. The widths of connecting lines between different treatment nodes reflect the number of studies available for each comparison. DOAC indicates direct oral anticoagulant; LAAC, left atrial appendage closure; RCT, randomized clinical trial; and VKA, vitamin K antagonist.

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  Figure 3. Ischemic and bleeding outcomes. Forest plot reporting odds ratios (OR) and 95% CIs for the primary and secondary end points.

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  Figure 4. Bivariate plot for primary efficacy and safety end points. In this plot, the relative effects of LAAC and VKAs as compared with DOAC (reference, dotted lines) both in terms of stroke or systemic embolism (horizontal axis) and major bleeding (vertical axis) are contemporary plotted. Circles indicate the odds ratios, whereas the lines indicate the 95% CIs. DOAC indicates direct oral anticoagulant; LAAC, left atrial appendage closure; and VKA vitamin K antagonist.