Why the study?
Does age or sex predict stroke recurrence and death in patients with embolic stroke of undetermined source?
Does age or sex predict stroke recurrence and death in patients with embolic stroke of undetermined source?
Age is a strong predictor of stroke recurrence and mortality in ESUS, highlighting that age distribution in clinical trials may significantly influence their statistical power.
Age distribution may affect ESUS trial power; hypothesis-generating for age-stratified prevention strategies.
Age, but not sex, is a strong predictor of stroke recurrence and death in ESUS. The risk is ≈3- and 8-fold higher in patients >80 years compared with those <60 years of age, respectively. The age distribution in the ongoing ESUS trials may potentially influence their power to detect a significant treatment association.
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Ntaios et al. (2017) studied this question.
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