What question did this study set out to answer?

To elucidate the paradoxical biological roles of transforming growth factor β (TGF-β) as both an endogenous tumor suppressor and a promoter of malignant progression.

July 14, 2003Proceedings of the National Academy of SciencesOpen Access

The two faces of transforming growth factor β in carcinogenesis

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Authors

ARAnita B. RobertsBoston University LWLalage M. WakefieldNational Cancer Institute

Discussion

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Implication

Scientific review reveals the biphasic behavior of transforming growth factor beta in neoplastic cells, highlighting targets for stage-specific cancer therapies.

Key Points

To elucidate the paradoxical biological roles of transforming growth factor β (TGF-β) as both an endogenous tumor suppressor and a promoter of malignant progression.
Synthesized molecular and cell biology evidence examining TGF-β pathway signaling across early-stage and advanced neoplastic models.
Analyzed cell-cycle regulatory mechanisms, transcriptional targets, and phenotypic adaptations governing malignant transformation.
TGF-β mediates tumor suppression in normal tissues and early lesions by triggering cell cycle arrest in G1 and inducing programmed cell death.
Malignant cells bypass TGF-β-induced growth inhibition via receptor or pathway mutations while co-opting downstream signaling to stimulate motility and survival.
Elevated TGF-β activity during advanced stages drives epithelial-mesenchymal transition, remodeling of the extracellular matrix, immune evasion, and metastatic dissemination.

Cite This Study

Roberts et al. (2003) studied this question.

synapsesocial.com/papers/69de79b77ed287395e558f45 https://doi.org/10.1073/pnas.1633291100

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July 14, 2003Proceedings of the National Academy of SciencesOpen Access

The two faces of transforming growth factor β in carcinogenesis

View Full Paper

Ask AI

Bookmark

Authors

ARAnita B. RobertsBoston University LWLalage M. WakefieldNational Cancer Institute

Discussion

Member takes

Implication

Scientific review reveals the biphasic behavior of transforming growth factor beta in neoplastic cells, highlighting targets for stage-specific cancer therapies.

Key Points

To elucidate the paradoxical biological roles of transforming growth factor β (TGF-β) as both an endogenous tumor suppressor and a promoter of malignant progression.
Synthesized molecular and cell biology evidence examining TGF-β pathway signaling across early-stage and advanced neoplastic models.
Analyzed cell-cycle regulatory mechanisms, transcriptional targets, and phenotypic adaptations governing malignant transformation.
TGF-β mediates tumor suppression in normal tissues and early lesions by triggering cell cycle arrest in G1 and inducing programmed cell death.
Malignant cells bypass TGF-β-induced growth inhibition via receptor or pathway mutations while co-opting downstream signaling to stimulate motility and survival.
Elevated TGF-β activity during advanced stages drives epithelial-mesenchymal transition, remodeling of the extracellular matrix, immune evasion, and metastatic dissemination.

Cite This Study

Roberts et al. (2003) studied this question.

synapsesocial.com/papers/69de79b77ed287395e558f45 https://doi.org/10.1073/pnas.1633291100

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