Does left ventricular stiffness modulate end-diastolic pressure and stroke volume during physiological stress in patients with HFNEF?
Left ventricular stiffness modulates cardiac function during stress in HFNEF, highlighting it as a potential therapeutic target.
Increased left ventricular stiffness contributed to increased end-diastolic pressure during handgrip exercise and decreased stroke volume during atrial pacing in patients with HFNEF. These data suggest that left ventricular stiffness modulates cardiac function in HFNEF patients and suggests that diastolic dysfunction with increased stiffness is a target for treating HFNEF.
Westermann et al. (Mon,) studied this question.