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July 25, 2013Thyroid

Effects of Silencing the RET/PTC1 Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol

Hafiz Muhammad Ali Andrei Maksimenko Giorgia Urbinati Hubert Chapuis Mouna Raouane Didier Desmaële Yasuhiro Hayashi Hideyoshi Harashima Patrick Couvreur Liliane Massaad-Massade

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Abstract

Conversely to siRNA RET/PTC1-SQ NPs, the siRNA RET/PTC1-SQ GALA-Chol NPs are efficient in vitro but not in vivo. Finally, NPs of siRNA RET/PTC1-SQ were found to be efficient silencers of the RET/PTC1 fusion oncogene in in vivo applications even at a concentration lower than used in a previously published study.

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Ali et al. (2013) studied this question.

synapsesocial.com/papers/69de7e3d7ed287395e55939a https://doi.org/10.1089/thy.2012.0544

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