Endothelium-dependent vasodilation is deficient in primary pulmonary hypertension, potentially contributing to abnormal vascular tone.
Deficient pulmonary endothelial function may worsen vascular tone; hypothesis-generating for targeted therapies and requires prospective validation.
Endothelium-dependent vasodilation is deficient in the pulmonary circulation of patients with primary pulmonary hypertension and may contribute to the abnormalities of pulmonary vascular tone and reactivity seen in that condition.
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Brett et al. (1996) studied this question.
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