Why the study?
Does neutralization of TNF-α reduce renal fibrosis and hypertension in rats with renal failure?
Does neutralization of TNF-α reduce renal fibrosis and hypertension in rats with renal failure?
Neutralization of TNF-α reduces renal inflammation, fibrosis, and blood pressure in a rat model of renal failure, suggesting a pivotal role for TNF-α in renal injury progression.
Neutralization of TNF-α in rats with renal failure decreases NF-ĸB activity that is associated with a reduction in renal TGF-β1 and ET-1 production, and an improvement of NO release. These effects likely reduce renal inflammation and fibrosis, and blood pressure indicating a pivotal role for TNF-α, at least, in the progression of renal injury.
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Therrien et al. (2012) studied this question.
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