April 1, 2002Molecular TherapyOpen Access

In Vivo Gene Delivery to Synovium by Lentiviral Vectors

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Population

Human and rat synoviocytes and chondrocytes and immunocompetent and immunocompromised rats

Design

Preclinical

Follow-up

up to 6 weeks

Authors

EGElvire GouzeBoston University RPRobert PawliukBrigham and Women's Hospital CPCarmencita PilapilBoston University

Discussion

Member takes

Implication

Supports lentiviral gene delivery in arthritis models; leaves open clinical translation from this animal study.

Structured PICO

Population

Human and rat synoviocytes and chondrocytes (in vitro) and immunocompetent and immunocompromised rats (in vivo)

Intervention

Intra-articular injection of VSV-G pseudotyped, HIV-1-based lentiviral vectors containing a beta-galactosidase/neomycin resistance fusion gene or human interleukin-1 receptor antagonist (IL1RA) cDNA

Outcome

Transduction efficiency and transgene expression in articular tissuessurrogate

Lentiviral vectors are capable of efficient in vivo gene transfer to the synovium, suggesting potential utility for long-term gene-based treatments of arthritis.

Cite This Study

Gouze et al. (2002) studied this question.

synapsesocial.com/papers/69de80446e50a6aba3e94029 https://doi.org/10.1006/mthe.2002.0562

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In Vivo Gene Delivery to Synovium by Lentiviral Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

In Vivo Gene Delivery to Synovium by Lentiviral Vectors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider