Why the study?
Does IL-1Ra gene transfer into RA-SF prevent cartilage degradation in a SCID mouse model?
Population
SCID mice coimplanted with normal human cartilage and rheumatoid arthritis synovial fibroblasts (RA-SF)
Comparison
RA-SF transduced with IL-1 receptor antagonist… vs RA-SF transduced with a marker gene
Design
Preclinical
Follow-up
60 days
Authors
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IL-1Ra gene therapy merits exploration in RA; leaves open translation from this animal model to patients.
Does IL-1Ra gene transfer into RA-SF prevent cartilage degradation in a SCID mouse model?
Gene therapy using IL-1Ra-transduced synovial fibroblasts prevents cartilage degradation in a preclinical model of rheumatoid arthritis.
Müller‐Ladner et al. (1997) studied this question.