September 6, 2006New England Journal of Medicine358 citationsOpen Access
View Full PaperEnoxaparin versus Unfractionated Heparin in Elective Percutaneous Coronary Intervention
Structured PICO
Does enoxaparin reduce bleeding or ischemic events compared to unfractionated heparin in patients undergoing elective PCI?
P
Population
Patients undergoing elective percutaneous coronary intervention (PCI)
I
Intervention
Enoxaparin (single intravenous bolus of 0.5 mg/kg or 0.75 mg/kg)
C
Comparator
Unfractionated heparin
O
Outcome
Rates of bleeding and prevention of ischemic eventssafety
In elective PCI, a 0.5 mg/kg IV bolus of enoxaparin reduces bleeding compared to unfractionated heparin, though the trial was underpowered to assess ischemic efficacy.
Abstract
In elective PCI, a single intravenous bolus of 0.5 mg of enoxaparin per kilogram is associated with reduced rates of bleeding, and a dose of 0.75 mg per kilogram yields rates similar to those for unfractionated heparin, with more predictable anticoagulation levels. The trial was not large enough to provide a definitive comparison of efficacy in the prevention of ischemic events. (ClinicalTrials.gov number, NCT00077844 ClinicalTrials.gov.).