Why the study?
Does enoxaparin reduce bleeding or ischemic events compared to unfractionated heparin in patients undergoing elective PCI?
Does enoxaparin reduce bleeding or ischemic events compared to unfractionated heparin in patients undergoing elective PCI?
In elective PCI, a 0.5 mg/kg IV bolus of enoxaparin reduces bleeding compared to unfractionated heparin, though the trial was underpowered to assess ischemic efficacy.
Supports 0.5 mg/kg enoxaparin to minimize bleeding in elective PCI; extends LMWH dosing data versus UFH while leaving ischemic efficacy unresolved.
In elective PCI, a single intravenous bolus of 0.5 mg of enoxaparin per kilogram is associated with reduced rates of bleeding, and a dose of 0.75 mg per kilogram yields rates similar to those for unfractionated heparin, with more predictable anticoagulation levels. The trial was not large enough to provide a definitive comparison of efficacy in the prevention of ischemic events. (ClinicalTrials.gov number, NCT00077844 [ClinicalTrials.gov].).
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Montalescot et al. (2006) studied this question.
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