Why the study?
Does cyclophosphamide cause fatal cardiomyopathy at lower doses than previously reported?
Population
2 patients receiving cyclophosphamide in preparation for bone marrow transplantation with normal EKGs prior…
Design
Case_report
Authors
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May warrant cardiac vigilance at cyclophosphamide doses below prior thresholds; leaves open confirmation of a revised risk limit.
Does cyclophosphamide cause fatal cardiomyopathy at lower doses than previously reported?
Cyclophosphamide can cause acute, fatal cardiomyopathy at total doses as low as 144 mg/kg, which is lower than previously recognized.
Mills et al. (1979) studied this question.
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