Why the study?
Serial muscle biopsies in DMD clinical trials are critical to document therapeutic responses, but less invasive means of sampling muscle are needed.
Does vacuum-assisted core needle muscle biopsy provide safe and reliable high-quality tissue in healthy and dystrophic individuals?
Population
128 biopsy procedures in healthy and dystrophic adult and pediatric subjects
Comparison
Vacuum-assisted core needle muscle biopsy
Design
Retrospective consecutive case-series cohort at a single institution
Authors
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Supports feasibility of vacuum-assisted muscle biopsy; hypothesis-generating and requires validation before practice change.
Does vacuum-assisted core needle muscle biopsy provide safe and reliable high-quality tissue in healthy and dystrophic individuals?
Vacuum-assisted core needle muscle biopsy is a safe and reliable method to obtain sufficient high-quality muscle tissue for diagnostic and clinical trial applications in both children and adults.
Barthélémy et al. (2020) studied this question.
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