This study demonstrates that burning pain is signaled by modality-selective lamina I neurons and not convergent lamina V wide-dynamic-range neurons.
Animal data on lamina I selectivity for burning pain warrant clinical caution; leaves open human pathway validation.
Single-unit recordings from monkey spinothalamic tract (STT) neurons reveal that the responses of polymodal nociceptive lamina I STT neurons correspond with the profile of burning pain elicited in human subjects by repeated brief-contact heat. In contrast, lamina V wide-dynamic-range (WDR) neurons show a significantly different response pattern. This finding indicates that burning pain is signaled by modality-selective lamina I neurons and not convergent lamina V WDR neurons.
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A. D. Craig (2004) studied this question.
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