Is increased plasma TMAO associated with higher stroke risk in the general population?
Elevated plasma TMAO, but not its precursors, is associated with an increased risk of stroke in the general population.
Increased TMAO was associated with higher stroke risk in the community-based population, whereas the TMAO precursors carnitine, choline, betaine, and TML were not associated. Further studies are warranted to confirm these findings and to further elucidate the role of TMAO in the development of stroke.
Liu et al. (Thu,) studied this question.