Co-prescribing of anticholinergics and cholinesterase inhibitors occurs more frequently in younger, healthier nursing home residents with dementia, with infrequent deprescribing, indicating a potential prescribing cascade.
May signal prescribing cascade in dementia care; leaves open whether deprescribing improves outcomes in observational data.
Younger, healthier older adults with dementia were more likely to experience co-prescribing anticholinergics and ChEIs. Discontinuation of anticholinergics was infrequent. Further research is needed to understand prescribers' ability to recognize and reverse potential prescribing cascades through deprescribing.
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Gromek et al. (2022) studied this question.
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