Does coronary vascular dysfunction predict cardiac mortality in patients with and without diabetes mellitus?
Impaired coronary flow reserve identifies diabetic patients without known CAD who are at a high risk for cardiac mortality, comparable to those with established CAD.
Coronary vasodilator dysfunction is a powerful, independent correlate of cardiac mortality among both diabetics and nondiabetics and provides meaningful incremental risk stratification. Among diabetic patients without CAD, those with impaired CFR have event rates comparable to those of patients with prior CAD, whereas those with preserved CFR have event rates comparable to those of nondiabetics.
Murthy et al. (Thu,) studied this question.